Aviation Safety Network (ASN) database in its preliminary report stated that there were no passengers in the aircraft but recorded that the co-pilot and two police officials standing on the ground died of fatal injuries, and the four injured are now receiving treatment at Kathmandu's Grande Hospital. The aircraft had collided with a parked chopper at the airport.
At least four persons including Manang Air Pilot CB Gurung have been also been injured in the crash, the report added. "We are not sure about the cause of the accident".
The four passengers and a flight attendant were safe.
The incident occurred as the plane skidded off the runway while preparing to take off and hit helicopters parked at the Lukla-based helipad which is 30-50 metres from the runway, the Kathmandu Post reported.
Air crashes are common in mostly mountainous Nepal.
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Both airlines are private companies serving locals and tourists in the remote areas of Nepal.
According to Himalayan Times, the Summit Air plane was taking off for Kathmandu from the Lukla airport in the district. It is often referred to as one of the most hard and unsafe airports in the world because of a short runway (527 metres) and challenging terrain.
Last month, seven people, including the country's tourism minister were killed in a helicopter crash in eastern Nepal.
Nepal has been criticised for poor safety measures, with the European Union denying Nepalese airlines access to its airspace since 2013.