Sean O'Brien slots in at openside flanker after a knock to Josh van der Flier early in the French game forced him off. Jack Conan who made a strong impact off the bench against the French once again provides back row cover on the bench.
There are a couple of changes to the forwards as lock Tadhg Beirne makes his Six Nations debut in place of the injured Iain Henderson. Tadgh Beirne and James Ryan are partnered in the second row with Peter O'Mahony, Sean O'Brien and CJ Stander named in the backrow.
Scrum-half Kieran Marmion may get his first taste of Six Nations action this year off the bench, with Jack Carty and Jordan Larmour covering the rest of the backline.
Schmidt admitted he would have preferred not to have to throw Beirne in straight away. "If it was me I'd be concentrating on playing Scotland", joked Gatland. He will know his fellow Scarlets teammates very well.
Arsenal to face Napoli in Europa League last eight
So, included in today's draw are: Arsenal , Chelsea , Slavia Praha, Napoli , Benfica , Villarreal , Valencia and Eintracht Frankfurt .
"To say that was not his best performance, I know he'd agree with that", said Schmidt.
Beirne is one of three changes to the Ireland team who beat France last week.
The availability of Liam Williams is a major boost to their Grand Slam hopes.
Grizzled hooker Rory Best will lead out the side for the final time in the Six Nations as he will retire from the Test arena after the World Cup.
Rob Kearney, who was a late withdrawal last weekend, returns at full-back having recovered from a calf strain. Dave Kilcoyne 18. Andrew Porter 19.