The Weather Network reported at least three deaths via Missouri State Highway Patrol (MSHP).
Snow continues to fall for portions of Kentucky, but as temperatures hover around freezing a wintry mix could be seen in other areas. Colder pavement temperatures will also create several slick spots on untreated roads.
By late morning Saturday, officials had reported almost 11 inches of snow at Lambert International Airport in St. Louis, where most flights were canceled or delayed.
A dusting to an inch of snow is possible Saturday night for the northern Piedmont and counties bordering Virginia, the National Weather Service's Raleigh office said in an 11:30 a.m. briefing Saturday.
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"For the folks in South Central Pennsylvania northward into North Central Pennsylvania accumulations will range from little to nothing north of Route 80 to a 2 to 3 inch (isolated 4") amounts south of Route 76.
Some precipitation is expected Friday and Saturday in Boston, where only 0.2 inches of snow has fallen this winter, according to forecasters.
Almost 250 flights were canceled nationwide and another 400 delayed as of 10:45 a.m. If travel is a must, it advises the keeping of an extra flashlight, as well as food and water in one's vehicle in case of an emergency.