"Bohemian Rhapsody", about the late Queen frontman Freddie Mercury, bested another movie surrounded by music, the favorite "A Star is Born", to win best picture, drama and best actor in a drama for Rami Malek.
She is the first Asian woman to front a major awards show in the United States. Even aspiring Emirati designer Ahmad Alkhyeli managed to showcase his brand, with Lili Reinhart wearing a translucent red Khyeli Couture gown druing the awards ceremony.
Other winners included the Peter Farrelly comedy drama Green Book.
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Will Bradley Cooper, Lady Gaga and "A Star Is Born" cement their status as Oscar front-runners?
It was a big night too for Sandra Oh, who as well as hosting her first Globe ceremony was named Best TV Drama Actress for BBC America thriller Killing Eve.
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The 76th Annual Golden Globe Awards have come to a close, which means the victor for Best Motion Picture - Drama has been announced. Gaga accepted the award with co-writers Mark Ronson, Anthony Rossomando and Andrew Wyatt.
The two big awards of the night going to Bohemian Rhapsody was a surprise to some who thought A Star is Born was going to clean up on the night.
"The power of movies is that it brings us all together", he said.
The Mexican movie, which also took the prize for best director, is seen as an Oscar frontrunner in February.
A similar television achievement award was also launched this year, dubbed the Carol Burnett Award. "You have been my ally, my confidant, you are my love", Rami said.
"Does this mean I get to accept it every year?" she joked.