The crash occurred when a white Chevy pickup truck heading south in the northbound lanes hit an SUV head-on, investigators said, leaving the truck badly damaged while the SUV caught fire.
He added that Issam Abbas was a lawyer and that Rima Abbas was a doctor and devoted mother to their children.
The wreck happened around 3:30 A.M. Sunday on I-75 in Lexington, KY.
WKYT reports five people inside the SUV died along with the driver of the pickup.
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Authorities identified the family members as 42-year-old Issam Abbas and Rima Abbas, 38 and their children, a boy Ali Abbas, 14 and girls Isabella Abbas, 13, and Giselle Abbas, 7.
They were traveling home to MI from a Florida vacation.
The driver of the pickup truck, a 41-year-old Joey Bailey of Georgetown, Kentucky, was also killed in the crash.
The Lexington Police Department is now asking for help from anyone in the public who may have seen the white pickup truck prior to the collision.
Anyone with information on the crash is asked to contact the Collision Reconstruction Unit at 859-258-3663.