The former first lady was speaking at a book event at the Barclays Center in Brooklyn when the swear word slipped out, sparking a tsunami of shock and delight across the 19,000 seater arena - and on social media.
Michelle Obama, the former USA first lady, has said she still feels imposter syndrome despite her eight years as America's most powerful woman and her success as an advocate for women and girls across the world. I tell women that whole "you can have it all" - mmm, nope, not at the same time, that's a lie.
"It's not always enough to lean in, because that s-t doesn't work all the time", Obama said.
Mrs Obama added that her husband had always had a great affection for the Queen, saying: "Barack is so incredibly fond of Her Majesty and I won't go into his fangirling but I think it's because she does remind him of his grandmother Toot, she's smart and amusing and honest".
She added: "The person whose job it was to help young people reach their dreams, she saw me and whatever she saw in me told me that my dreams were too high". In her autobiography Becoming, which she is in Britain to promote, Mrs Obama spoke of the impact that first visit had on her.
"Marriage still ain't equal, y'all", Mrs. Obama told some 19,000 audience members on Saturday.
"Thankfully I get more (and more regular) sleep these days", she said. Facebook has since put out a statement saying that Sandberg "takes full responsibility for any activity that happened on her watch".
She continued: "Overall, we are not seeing a major increase in female leadership in any industry or in any government in the world, and I think that's a shame".
"And what better way to do it than to make you think you don't belong?"
"Our Secret Service doesn't even let me ride around with Malia so up until that point we had never driven in a vehicle driven by anyone else, so it was like 'this is what's going to happen, you're going to get out and sit here and this is what is going to happen". She starts leaning back.' Although couched in terms of encouragement, Sandberg's exhortation contains more than a note of reproach. "I find great hope in this generation of young women". "So oftentimes it's not equal and you feel a bit resentful and so then it's time to go to marriage counseling".
To combat that, the Duchess of Sussex should not be afraid to play a longer game. "Kids are an interrupter; they mess it all up".
Forbes' top-earning vlogger is only 7, earns $22 million
Since launching his main channel in 2015, Ryan has amassed more than 17 million followers and close to 26 billion views. A 7-year-old boy who reviews toys has been revealed as YouTube's highest-earning star, raking in $NZ 31.7million.