Australia's Jason Scrivener has kept himself in touch with the early frontrunners after the opening day of the Nedbank Golf Challenge in Sun City, South Africa.
Garcia, twice a Sun City victor before the Nedbank became part of the tour, made eight birdies in a brilliant start to the penultimate tournament of the season to move four strokes clear of Charl Schwartzel, Mike Lorenzo-Vera and Mikko Korhonen at the Gary Player Country Club. Oosthuizen, who is from South Africa, has never won his country's most prestigious tournament.
Rory McIlroy, who needs a top-two finish to keep his Race to Dubai hopes alive, is one under par after a second-round 71.
Mikko Korhonen (70) was third at 6 under, two behind Oosthuizen and three off the lead.
Sergio Garcia is in the lead and that's all that matters for the two-time champion after an up-and-down second round for the Spaniard at the Nedbank Golf Challenge at Sun City on Friday.
"I wouldn't say it was a frustrating back nine‚" said a pragmatic Garcia.
New Zealand's Ryan Fox however has made a good start with a round of 69 to be 2 under and in 11th place.
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"It's a tournament I've always wanted to play as a kid and came here plenty of times with the family to watch", he said.
"It wouldn't have been the year that I would have envisioned at the start but you're not going to have those years every single year that you play".
English pair Lee Westwood and Aaron Rai share fourth spot alongside Dylan Frittelli and Shane Lowry, with Thomas Detry in the group a further stroke back after a round-of-the-day 66. Also in that group is Lee Westwood (69), a two-time victor at Sun City.
England's Ross Fisher blazed his way eight-under for the round but came unstuck on the par-four 15th where he carded a nine.
Former Masters champion Garcia, 38, is on 10 under after his one-under par 71, with South Africa's Louis Oosthuizen remaining on eight under after his 72. He then found trees again and lost his ball.
McIlroy's front nine was promising with three birdies offset by just a single bogey, at the par-four third when his ball plugged just below the lip of a greenside bunker.