City took just six minutes to open the scoring as Wesley Hoedt smashed an attempted clearance of Leroy Sane's cross into his own net, before Sergio Aguero doubled their lead by tapping in Raheem Sterling's cross. The Germany worldwide played a short ball across goal and Hoedt diverted it into the back of his own net.
City restored its three-goal cushion on the stroke of halftime with Aguero taking advantage of a mistake by Cedric Soares and crossing for Sterling to score his fifth league goal of the season.
And it was soon three, with Sterling involved again.
The visitors initially improved after the break, with James Ward-Prowse and Ings forcing Ederson into three vital saves between them.
Palace's hopes of securing a crucial point vanished when they conceded two goals in five second-half minutes.
What does it mean?
"Seeing that happen you think we need to be more aggressive and determined in our defensive play and we can't allow those players time and opportunity to affect us like they were doing". That in itself is impressive. The England global was absolutely everywhere, no wonder he is reportedly in line for a new five-year contract.
Lanka IOC reduced fuel price
Before the price cut, petrol in Delhi had hit an all-time high of Rs 84 per litre and diesel was at record Rs 75.45. Fuel prices have been declining since early October as oil companies factored in softening of worldwide rates.
Sterling has now scored or assisted eight goals in his 12 appearances this season with the strikes against Southampton his third and fourth this campaign.
- Southampton are winless in nine games at the Etihad Stadium (D1 L8) since winning their very first game there in April 2004.
The Premier League title race this season may be one of the most keenly contested in recent times as teams continue to breathe down each other's neck for the top position.
Alvaro Morata scored twice as unbeaten Chelsea climbed to second in the Premier League with a 3-1 victory against Crystal Palace on Sunday.
One goal became two six minutes later as the division's highest scorers went through the gears, with Aguero tapping in at the back post for his landmark 150th Premier League goal following some good work from Sterling.
- Sterling scored his 50th goal in all competitions for the club in what was his 153rd game and 126th start.