Purdue also set a school record for points scored against the Buckeyes, besting the previous mark of 41 in 1967.
ABC's Saturday Night Football showdown featuring the upset of No. 2 Ohio State at Purdue (7:30 p.m. ET) delivered a 4.2 overnight rating, ranking as the top college football game of the day and marking the seventh straight Saturday that the highest-rated primetime game aired on ESPN/ABC.
Blough outplayed Heisman Trophy candidate Dwayne Haskins Jr., finishing 25-of-43 for 378 yards and sealing the victory with a 43-yard scoring pass to Rondale Moore with 3:37 to play. But he missed receivers down the field on a windy night at Ross-Ade Stadium and was almost picked off a couple of other times before Markus Bailey's 41-yard interception return for a score.
The Buckeyes were called for 10 penalties and faced their largest halftime deficit of the season, 14-3, before giving up four scoring plays of more than 40 yards in the fourth quarter.
Ohio State has a neutral-site nonconference win against TCU and a road win at Penn State, and it could further impress the committee with a win at Michigan State on November 10 and a home win over rival Michigan on November 24, plus the Big Ten title game.
The game was delayed for 1 hour, 15 minutes in the first quarter because of lightning in the area. (Ohio State also had lost earlier to Oklahoma.) It was the second straight year that the Big Ten champion was left out of the top four and a reminder that there's no guarantee in a system as subjective as the playoff.
The Spartans (4-3, 2-2) struggled to move the ball, getting held to 94 yards and failing to convert any of its 12 third downs. The biggest stop came late in the third quarter.
It is still too early to go insane over the College Football Playoff implications for Ohio State with this loss, because a one-loss Big Ten champion - be it Ohio State or MI - would still figure to have a solid chance of being one of the four teams selected at the end of the year.
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"What happened past year versus Iowa. we can still make the Big Ten championship and do what we do to possibly make the playoff", said Ohio State quarterback Dwayne Haskins.
The Buckeyes reached the red zone (i.e. inside the opponent's 20) five times - really just four; the game ended with Ohio State at the 17, counting as a red-zone trip - and left with just two field goals to show for it.
Johnathan Thomas took the ensuing kickoff back to the IN 5, setting up McSorley for the go-ahead touchdown on the next play. Five plays later, McSorley almost walked into the end zone to make it 33-21 lead.
The Hoosiers added a late touchdown Peyton Ramsey's 21-yard pass to Harris, and recovered an onside kick. Haskins finished 49/73 for 470 yards two touchdowns and an interception.
The Buckeyes (7-1, 4-1 Big Ten) now limp into their off week, literally and figuratively.
Prior to both of those field goals, cornerback Antonio Blackmon broke up would-be touchdowns on third down.
Ivory Kelly-Martin ran for 98 yards for Iowa, which had its first shutout since a 28-0 victory at IL two years ago.
Against a Buckeyes team that came in averaging 46 points per game, the fifth-most in the nation, the Purdue defense was the story of the night. Saturday's was the Buckeyes' fifth loss in eight games this century there. The Boilermakers dominated the first half by playing keep away. Devine Ozigbo ran for 152 yards, Martinez for 125 and Maurice Washington for 109.