Casemiro and Mariano Diaz hit the woodwork with headers, but Marcelo's strike with 20 minutes remaining kept Madrid's hopes of a recovery alive and ended the club's run without a goal in all competitions at 480 minutes.
Los Blancos suffered an immediate setback when José Luis Morales Nogales opened the scoring in the opening ten minutes of the first-half.
"Right now that is the last thing that I'm thinking about", said Lopetegui when asked if he was anxious about losing his job. "I am thinking only about lifting the players".
Levante were then awarded a penalty in the 13th minute when the Video Assistant Referee (VAR) adjudged Raphael Varane to have handled in the box.
Real Madrid and Barcelona can not avoid heading into next week's Clasico under pressure but each have two games to lift the mood at least, ahead of the pivotal clash at the Camp Nou.
"I feel more encouraged than ever to continue because the team gave their heart and soul on the pitch".
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The Dodgers acquired Machado from Baltimore this season for their playoff push, and to replace injured shortstop Corey Seager . Brewers manager Craig Counsell wasn't concerned the incident would distract from his team's focus in the best-of-seven series.
"For the effort they have made and for how they have reacted to their misfortune". We are focusing only on the Levante game, there is no larger objective.
Their offensive troubles have led to increased speculation that they are ready to launch a huge bid for a world-renowned player next summer, with Paris Saint-Germain ace Neymar and Chelsea's Eden Hazard two of the targets that they are most readily associated with. Marco Asensio also had a first-half goal disallowed by VAR.
"Stats do not count much in football - it is goals that count".
Meanwhile, Lopetegui went on to explain he was focused on his work as the manager of Real Madrid, which was now occupying the fourth spot in the La Liga standings, two points behind top placed Sevilla.
They have two home games to clear the fog, and winnable ones too, against Levante in La Liga on Saturday before Viktoria Plzen visit on Tuesday in the Champions League.
He said: "I'm not anxious about what people are saying, I'm not taking much notice". "I worry about quickly picking up the boys and keep believing, because it's the only way to change this run".