"Air strikes reduce Al-Shabaab's ability to plot future attacks, disrupt its leadership networks, and degrade its freedom of maneuver within the region", Africa Command said in a statement.
Africa Command said Friday's strike "was the largest airstrike against al-Shabaab since November 21, 2017, when United States forces conducted an airstrike against an al-Shabaab camp killing approximately 100 terrorists". The Al-Qaeda-linked Al-Shabaab aims to topple Somalia's UN-backed government and impose its own strict interpretation of Islam.
The strike targeted the militants associated with the group al-Shabaab, al Qaeda's largest affiliate.
Two officials tell The Associated Press that several missiles were fired Friday by two unmanned US drones. That is on pace to surpass last year's attacks against the group.
It was the largest USA air strike since a November 2017 attack, which killed about 100 al-Shabab fighters.
The officials spoke on condition of anonymity because they were not authorized to speak to reporters.
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More than 500 American personnel are partnered with Somali forces and AMISOM, which aims to counter the threat from Al-Shabaab jihadists. As a result of the actions of the military killed 60 people.
At least two Somali soldiers were killed and two others injured in a fierce fighting with al-Shabab militants in Hiraan region of central Somalia on Tuesday.
US President Donald Trump expanded military operations against al-Shabab in March 2017.
The US military's activities in Somalia have been under scrutiny in recent months after US special forces in May were accused of complicity in a botched raid by Somali troops that left five civilians dead.
So far this year in Somalia, the United States has conducted 27 strikes, including by drone, mostly against small numbers of Al-Shabab fighters.
Since 2007, the USA military's combat drones have waged war against al-Qaeda's affiliates in Somalia, among them Al-Shabaab.