With Bale injured and therefore unavailable for Tuesday's Uefa Nations League clash with the Republic of Ireland, Wilson took the opportunity to prove that Wales are far from a one-man team as he curled home a gorgeous free-kick on the hour-mark.
Wilson has been one of the stars for the Rams this season, and will certainly be impressing Jurgen Klopp, who will be relishing his return to the Liverpool setup in the future, but tonight's winning free-kick maintained Wales' dominance over the Irish team that are struggling for form of late.
Ryan Giggs' compared Harry Wilson's free-kick expertise to former Manchester United team-mate David Beckham after he scored the victor in Wales' win over Republic of Ireland.
Wales tested him and coach Gareth Bale said he "had something". 'He does it all the time in training, it's practice, practice, practice'.
O'Neill's men now have just a single point from their two Nations League fixtures and will be looking to avenge a 4-1 reverse at the hands of Wales back in September.
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After van Dijk's opener, the Dutch had chances to double their lead but Wijnaldum shot wide and Depay headed off target.
Wales are now two points ahead of Denmark and would win the group by beating them in next month's match in Cardiff.
It's not easy when you miss players of that quality, but the players who stepped in did brilliant. Even the substitutes coming off the bench, everybody contributed.
Giggs added: 'I'm so proud, they dug in right to the end. I don't want to pick out one name, but Ashley Williams was outstanding for 90 minutes.
We created no real chances, and the only time we looked like scoring was when Denmark literally stopped playing for a few seconds. It was a real captain's performance.
"They have a great spirit, we lack a little bit of technical ability".