And after a day in which Boris Johnson stole the show at the conference with his chuck Chequers onslaught, the Prime Minister will attempt to re-assert her authority.
On the final day of her party's annual conference, Mrs May sought to rally members by addressing their concerns that the Conservatives are becoming increasingly directionless under the weight of Brexit, urging them to look to a brighter future.
May, who received a standing ovation after dancing onto the stage to Dancing Queen by ABBA, said she was confident that she could clinch a deal with the EU.
It was a warm welcome for a leader whose fragile position at the helm of her party has come under further pressure after the European Union rejected parts of her so-called Chequers plan and critics stepped up calls for her to ditch her strategy on Brexit, Britain's most far-reaching policy shift for more than 40 years.
May also made some self-deprecating quips about her disastrous conference keynote speech a year ago, which was punctuated by a severe coughing fit and a comedian handing her a P45 - the tax form issued to employees who have been dismissed from their job in Britain and Ireland.
Then the thing we saw immediately afterwards was that tweet about the Strepsils and the speech and we laughed along with her and she showed that humorous side of her. "If we don't, if we all go off in different directions in pursuit of our own visions of the flawless Brexit, we risk ending up with no Brexit at all", she said.
She added: "Don't let anyone tell you we don't have what it takes: we have everything we need to succeed".
Man makes shocking discovery about 30-year-old doorstop
The man, who has asked to remain anonymous, knew the 22-pound rock came from outer space ever since he bought the house in 1988. A mineral museum in ME also was considering buying it, and the owner herself - a collector - said she might purchase it.
May will tell delegates that Britain's "best days lie ahead of us" and that countries across the world stand ready to trade with the United Kingdom once it leaves the European Union in March 2019. She also signalled an end to the almost decade-long austerity drive. Forty-eight lawmakers would be needed to trigger a vote of confidence.
Referring to those comments Thursday, O'Neill told CNBC that the "slightly unfortunate words" were "unbecoming of a chair of Chatham House", but said politicians like Hunt and Johnson were just trying to appeal to pro-Brexit members of the Conservative Party.
James Forsyth, political editor of the Spectator magazine and a columnist at the Sun newspaper said: "May delivers one of her best speeches, and will send activists home in better heart than they expected this morning".
The reprise of the dance steps from her recent African trip surprised not only Tory delegates and TV viewers but even her closest aides and husband Philip, as May had kept her plans secret.
We talk to Brexit Secretary Dominic Raab and Brexiteer and former Tory leader Iain Duncan Smith.
Numerous eurosceptic Conservative MPs have already drawn big crowds in Birmingham as they offer their own idea for a looser trade arrangement with the EU.
The Prime Minister returned the favour by namechecking her opponent seven times. Acknowledging that "there are plenty of prominent people in British politics - in Parliament and out of it - who want to stop Brexit in its tracks", she dismissed demands for a second referendum - called the "people's vote" - on the ground that people are now more aware of the cost of Brexit. This is not taking back control: "this is forfeiting control", he said.