Linebacker Reuben Foster, who returned from a two-game suspension, was the team leader with six tackles and caused a scare when he left the field with an injury early in the fourth quarter. "I haven't had a chance to see him yet, but I feel for him". Sherman suffered a calf injury that knocked him out of action, while Garoppolo may have tore his ACL.
He completed 20 of 30 passes for 251 yards and two touchdowns before leaving the 38-27 loss.
San Francisco proceeded to kick it deep rather than try an onside kick. Still, Nelson's intentions are questionable here, as Garoppolo appeared to be heading out of bounds after getting past the first-down marker.
Garoppolo crumpled to the ground, where he received immediate medical attention.
Patriots Nearly Traded Rob Gronkowski to the Lions
He was removed from New England's injury report Friday after being limited in Wednesday's practice because of an ankle injury. Rather than suit up for their team, Gronkowski would have forgone the rest of his National Football League playing career.
Soon after, Garoppolo left the game on a cart and did not return.
Mahomes finished with 314 yards passing in his first regular-season start at Arrowhead Stadium, and his touchdown throws to Conley, Demetrius Harris and Sammy Watkins gave him 13 this season without an interception.
Unfortunately for San Francisco, its defense will be without strong safety Jaquiski Tartt (shoulder).
Garoppolo, 26, will have an MRI on Monday to confirm the extent of the injury, but the initial prognosis within the team is not positive. And in the second quarter, free safety Adrian Colbert left the game with a hip injury.