Joshua has promised a breaking down job, the crowd will want a knockout and Povetkin will be determined to crash the Wembley party.
His most recent win came against Joseph Parker at Cardiff's Principality Stadium in March where he was taken the distance for the first time but a points win saw him add the WBO title to his WBA, IBF and IBO heavyweight titles. The one loss came at the hands of Klitschko back in 2013.
The defending champ is reportedly guaranteed £20 million for his 22nd professional outing while Povetkin can expect to pocket £6 million.
American Deontay Wilder holds the WBC belt but the fans will have to wait for that long-desired match-up.
The London 2012 Olympics gold medallist defeated Klitschko at Wembley on April 29, 2017 to win the WBA world heavyweight title.
The Povetkin clash was agreed on after both camps of Joshua and WBC world heavyweight title holder Deontay Wilder failed to agree on talks for a unification fight.
Povetkin, like Joshua a former Olympic champion with his moment of glory coming in Athens in 2004, served notice of his punching power on the undercard of that bout, with a sickening knockout of Britain's David Price. "Because one punch can change the course of a fight, you are in there for 12 rounds".
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Povetkin said after the weigh-in he was not bothered by the development.
"It's a very comfortable and good weight for me, I feel great", he said, via a translator.
"I didn't see anything in his (Joshua's) eyes. I know how to fight, but the question is what I can take when it comes back".
"The very least I will do is give everything I have".
"When I fought Klitschko, I was much weaker and in worse shape than I am now", he said.
When it was put to Joshua that losing would not end his career, he replied: "One hundred percent and I know that it could happen because I know how tough this sport is".