France's World Cup-winning captain Lloris is "expected to be out for several weeks" with a thigh injury according to the club, while manager Mauricio Pochettino is more hopeful Alli could return in time for the trip to Brighton on September 22.
All that happened yesterday is not good and he does not feel great. "He said he is sorry and he is a man and accepts his mistake".
Lloris was recently handed a 20-month driving ban and fined £50,000 after pleading guilty to drink driving.
Pochettino confirmed that Lloris would remain captain despite his drunk-driving case, replying "of course" when asked whether that would be the situation. He made a mistake and he's suffered the punishment of society.
"He's punishing himself. But of course we're not God, that we can judge people".
"He's the first that told me: 'Gaffer it's a massive mistake and I need to pay, like a man'".
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Tottenham will also be without Dele Alli, who picked up a hamstring injury on worldwide duty with England. "I am disappointed because we are going to miss him for this game and maybe the Champions League game against Inter Milan [on September 18]".
He added: "Lloris will have another scan to see the evolution of his injury".
Alli completed the full ninety minutes during England's opening defeat to Spain in the Nations League last weekend but it soon emerged that the midfielder had sustained a muscle problem during the game.
And he admits that the pair will need to be on top of their game on Saturday when Liverpool look to bury the memories of last season's embarrassing defeat against Tottenham.