"That is my first reaction".
"Sergio Aguero has looked sharp so far this term and City's all-time record goalscorer has scored 11 times in his last seven Premier League games at the Etihad - I feel he might be back amongst the goals at the weekend".
But as that would leave City playing only once at home in their final five matches, Guardiola is not keen.
City are spoiled for midfield choice as Juergen Klopp, manager of rivals Liverpool, noted on Friday when he told Sky Sports how sorry he was about De Bruyne's misfortune.
Guardiola has confirmed Kevin De Bruyne is likely to be sidelined for three months and revealed the tear of lateral ligaments in his right knee was down to fatigue.
"He will be a big miss", he said.
"Nobody pushed him, he chose to finish his global career so he could rest a little bit more with his wife, family and his little boy while continuing to play with us".
Vincent Kompany will make his made 248th Premier League appearance today.
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"No surgery is required and the midfielder is expected to be out for around three months".
Guardiola speculated that the extensive demands on players and the lack of a break over a demanding World Cup summer may have been a contributory factor to De Bruyne's injury.
De Bruyne was given three weeks off after the World Cup, having played over 500 minutes of action in helping Belgium reach the semi-finals at Russian Federation 2018.
Sitting pretty at the beginning of March after a win over Arsenal, City were 16 points clear at the top, and were closing in on their third Premier League title.
The eight-part series follows Pep Guardiola and his City team on their Premier League title-winning journey during the 2017-18 campaign.
"My advice to him now would be to rest and take the holidays he didn't get after the World Cup".
"Last season we put ourselves in a hard position, because to do better we can only finish first", he told Sky Sports News.