The Argentine came up against the Gunners on three occasions last season and directly contributed to a goal in each of those, registering one assist and scoring twice himself - including once in the EFL Cup final.
"In my career I want leaders..."
Predictions, Gooners? Let us know in the comments... That's the basic principle. Eliaquim Mangala and Danilo are injured while World Cup starters Kevin De Bruyne and Raheem Sterling are expected to play after a late return to the side.
Catching City isn't the immediate target for the Gunners, who last won the title in 2004.
"That's the dream", Guardiola said. "A win helps to win more". It is a Super Sunday clash that will see the defending champions travel to the Emirates Stadium.
"We do work on different formations in training".
Guardiola has said losing is his greatest fear and says his players must be motivated by how they got over the line in spectacular fashion last season.
"It is impossible to have the season all the time that is flawless".
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Speaking ahead of his side's opening game at Arsenal, Guardiola said: "We were the best, definitely, no doubts about that, but we don't play alone".
Guardiola's intensity was matched by his managerial counterpart on the sidelines but Arsenal struggled to get close to City on the pitch.
"Now he is at Arsenal, one of the best teams in England, and he is a contender to win titles".
"We are excited. We have a lot of ambition to start [well] on Sunday against the last winners of the Premier League".
While others bemoaned their lack of signings and questioned their club hierarchy's pre-season preparations, most notably Guardiola's nemesis in the red half of Manchester Jose Mourinho, the Catalan had nothing but praise for his squad and his employers, saying "I can not complain for one minute".
"Or Manchester United. People ask how will they do, but I know a little bit about the manager and in that situation how good they handle that". That's why it is nice.
Bernardo Silva, who impressed during pre-season in midfield is another option for City to replace Silva.
"We can be excellent, but others can be too - there can be six contenders".