On the most crucial point of the match, Anderson recovered after a fall and hit a lefty forehand to go up 0-30 while Isner was serving at 24-24.
The roof was closed and the floodlights turned on following Anderson's win.
And another all-time great awaits him on Sunday in either Nadal or Djokovic.
The pair slugged it out on Centre Court for six hours and 35 minutes before the eighth seed came through 7-6 (8-6) 6-7 (5-7) 6-7 (9-11) 6-4 26-24. He would go on to break the big American and then served out the match.
The two are meeting for the second time in ten years.
At this rate, they may not even get on court...
Why WWE Didn't Mention Brock Lesnar's UFC 226 Appearance On Raw
McMahon hopes fans will think that Brock Lesnar has turned his back on WWE and that it will be up to Roman Reigns to save the day. Mike Johnson from PWInsider reported that we might not see Lesnar for a while so a SummerSlam match is not guaranteed.
As Isner served for a 16-15 lead, the match became the second-longest Wimbledon singles clash at just over five and a half hours.
With the players tied at 16-16 in the deciding set, they had gone past the 5 hours, 31 minutes that a third-round match between Sam Querrey and Marin Cilic took in 2012.
Roanic had only been broken three times this Wimbledon previously but Isner doubled that tally alone to triumph 6-7, 7-6, 6-4, 6-3.
The 32-year-old stunned the tennis world on Wednesday when he beat defending champion Roger Federer in the Wimbledon quarter-finals, while Isner beat Canadian Milos Raonic in his quarter-final match. Anderson won the opening set before Isner bounced back to take the next two.
On Friday, Avenatti joined thousands of protesters at a central London march against U.S. President Donald Trump.
Competing for the University of Georgia Bulldogs between 2003-2007 and he had an awesome result in both singles and doubles, winning 283 matches for the Bulldogs overall!