Johnson rocked the Government by becoming the second Cabinet minister to resign in less than 24 hours.
He has served as health secretary since 2012.
Though they may have gone so close together, the manner of the departures of David Davis and Boris Johnson could not have been more different.
Johnson followed Brexit Secretary David Davis out the door as a hard-won government consensus on future trade ties with the bloc disintegrated less than three days after it was forged, and nine months before Britain is due to leave the EU.
Earlier in the day the EU Commission had "no specific comment" on the overnight resignation of Davis, which it said was "not a problem for the EU". "The dream is dying, suffocated by needless self-doubt", he wrote.
In her statement to Parliament, May attempted to give an impression of business as usual, saying she would present a detailed paper onThursday on the government's negotiating position for a post-Brexit relationship with the EU.
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A favorite among many on the right, Lee has never been a judge and was a prominent Trump critic ahead of the 2016 election. Kavanaugh's close ties to the Bush family, stemming from his five years in the White House under President George W.
Hunt told LBC Radio in October 2017, however, that he had changed his mind on the issue, in part because of what he said was disappointing "arrogance" in the EU's behaviour during negotiations.
The two departures shatter May's own proclamation of cabinet unity last Friday, when she believed she had, after two years of wrangling, secured agreement on Britain's biggest foreign and trading policy shift in nearly half a century. His appointment means that all four of the U.K.'s so-called great offices of state - Prime Minister, Chancellor of the Exchequer, Home Secretary and Foreign Secretary - are held by politicians who voted "Remain" in the 2016 referendum.
But leading pro-Brexit legislator Jacob Rees-Mogg said "I don't think a no-confidence vote is immediately in the offing".
We're "not there just yet - even if there's rumours of a leadership challenge", he added.
There have been differences within the Conservatives over how far the United Kingdom should prioritise the economy by compromising on issues such as leaving the remit of the European Court of Justice and ending free movement of people. "I'd have to do something I didn't believe in", he told the BBC.
In her Commons statement, May urged the European Union to take her proposal seriously. The direct effect of European Union law will end when we leave the EU.
Labour leader Jeremy Corbyn said Mr Johnson and Mr Davis had abandoned a "sinking ship", shattering the "illusion of unity" initially surrounding the Chequers plan.