With all of the top-10 seeds out of the tournament, Williams is the comfortable favourite heading into the last-eight - a status she's more than used to after a remarkable career spanning more than two decades. It's also a first for any Grand Slam tournament in the 50-year professional era. But also I've never been ranked where I am when this has happened before, so usually I'm one of those few seeds left that's still fighting and still in the tournament.
It took Mannarino so much toil and trouble to win one game, saving four break points to hold to begin the second set.
Since seeds were introduced in the 1920s, it's the first time none of the top-10 have reached the women's quarterfinals at Wimbledon.
Bertens, the first Dutchwoman to reach the last 16 since Michaella Krajicek, sister of former men's champion Richard, did so in 2007, followed up her win over Venus Williams in the third round with a display of power and poise. So it's really cool.
Rodina, who upset 10th-seeded Madison Keys in the previous round, broke back for 3-2 in the second set but was broken to love straight away.
His mastery was only the beginning of things for those who spent 120 pounds (about $160) to be at Center Court and were afforded the rare treat of watching three of the greatest to ever lift a tennis racket.
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Isner rode his big serve to beat Greek teenager Stefanos Tsitsipas 6-4, 7-6 (8), 7-6 (4).
Williams faces Camila Giorgi of Italy next, while 11th-seeded Angelique Kerber plays Daria Kasatkina of Russian Federation. I know it's more hard now, there are many more demands on your time etc and it was such a big title for her because she'd been in three finals before and for Romania blah blah blah... but really?
The 2017 French Open victor stormed into the last eight for the first time at The All England Club with a 7-6 (7-4) 6-0 victory in the first of 16 fourth-round singles encounters on so-called Manic Monday at Wimbledon.
The 21-year-old Ostapenko, the youngest player remaining in the women's draw, next faces 33rd-ranked Dominika Cibulkova of Slovakia.
Kevin Anderson advanced to his first Wimbledon quarterfinal after edging Gael Monfils, 7-6 (7-4), 7-6 (7-2), 5-7, 7-6 (7-4).