The newspaper tweeted a photo apparently from the scene, showing a lightly smashed up motorbike and vehicle, with a caption suggesting the auto had been turning and Clooney had made contact with its windscreen. The BBC reported the crash took place as Clooney was leaving his hotel in Costa Corallina, a beachside town in northern Sardinia.
Local daily newspaper La Nuova Sardegna reports Clooney's injuries are not serious, but that he was taken to the John Paul II hospital emergency room.
According to the site, George was said to be hit by a auto which suddenly changed direction at a spot close to a hotel.
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The daily says the 57-year-old Clooney had been headed to a film set on Tuesday (10 JULY 2018) when his motorbike was hit by a vehicle.
MailOnline has contacted a representative for George for comment.
Italian media report the accident happened in Sardinia where the United States actor is filming his latest TV series, Catch-22. In the show, Clooney stars as Colonel Cathcart.
Italian news agencies said Clooney suffered a minor knee injury in the crash.