Stefanos Tsitsipas was just 2 years old when Roger Federer, then a ponytailed 19-year-old with balletic grace, famously announced himself to the tennis world at Wimbledon in 2001 by toppling seven-time champion Pete Sampras in the fourth round.
Clearly dejected, Mannarino said afterward that he wasn't rattled by the Centre Court spotlight or the size of the crowd.
The victor of that clash will take on Kei Nishikori, who overcame a right arm injury to reach his first Wimbledon quarter-final with a gritty 4-6, 7-6 (7/5), 7-6 (12/10), 6-1 win over Latvian qualifier Ernests Gulbis.
He managed to finish off Russia's Karen Khachanov in straight sets in the gathering gloom on Monday.
This comes after Roger Federer took to channelling his inner Sachin Tendulkar while playing his Round of 16 match on Centre Court at the All England Club on "Manic" Monday.
"I'm more concerned the World Cup final will have issues because the Wimbledon final is going on."
On Monday, he nearly fell victim to the scheduling curse again. "I always enjoy playing against him", said Nishikori, who has beaten the Serb just twice in 15 meetings.
"[He has] this very calm aura that he brings on the court - that even if everything goes wrong, it still seems like everything is ideal and it's okay", said the 6-foot-4 Tsitsipas.
"Like previous year, I received the information that they can't reschedule my match on the other court because of the tickets that are presold".
"I guess there are other factors that play in".
Both Anderson of South Africa and the 44th-ranked Monfils of France were bidding to reach the quarterfinals for the first time on their 10th appearance at the All England Club.
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He is also the first Japanese man to reach the quarter-finals since Shuzo Matsuoka in 1995.
When asked whether he would rather not play Federer in the final, should they meet, Nadal said, "If he's in the final, I am excited to play Roger".
Federer seemed pleased that his opponent raised his level in the second set after a first set he described as "almost too easy".
"He's got weapons, a big serve and a big forehand", said Djokovic of the world number 40. He's played there a few more times than that.
Nadal has made the quarter-finals for the first time since finishing runner-up to Djokovic in 2011.
Nadal, chasing an 18th major, leads former US Open champion Del Potro 10-5 and Simon 8-1.
When asked if he was anxious about Sunday's World Cup final in Russian Federation clashing with the Wimbledon men's singles final, Roger Federer couldn't help but laugh.
'You can't plan for them anyway because one point can change the outcome of a set. "It's about being smart, no?"
Raonic fired 37 aces and 74 winners to defeat Mackenzie McDonald of the United States and reach the quarter-finals for the fourth time.
It won't be pretty.
Returning to Wimbledon on the back of a three-match run at Roland Garros - her comeback tournament after giving birth for the first time in September - the 2016 champion has swatted away her opposition for the cost of 24 games.