The aircraft was headed to the Wonderboom airport.
Nineteen people were injured when a plane crashed on Tuesday in a grassy area of the South African capital Pretoria, emergency services said, giving a preliminary toll.
ER24 spokesperson Russel Meiring said: "Services are now on the scene, they've been treating the patients".
Helicopters are on the scene to airlift any critical patients to hospital.
Jurgen Kotze, chief operating officer for Emer-G-Med services, said the crash was near Wonderboom airport on the Moloto Road.
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"Paramedics are treating the patients and will thereafter transport them to nearby hospital for further treatment".
"At this stage, we can confirm that crew members are attending to the scene of a crash", he said.
At the same time, Tshwane Emergency Services say four workers have been left critically injured after a plane hit a factory before crashing.
Civil Aviation Authority (CAA) spokesperson Kabelo Ledwaba said their investigators were on their way to the crash.